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血管平滑筋細胞の表現型変化に及ぼすエストロゲンと植物エストロゲンの影響の比較 : 動脈硬化抑制との関連からの検討
https://doi.org/10.18878/00001716
https://doi.org/10.18878/0000171615f773af-16fb-4e9b-8a66-a4b4500d4975
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004172311 (1.1 MB)
|
神戸女学院大学研究所
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-07-15 | |||||
| タイトル | ||||||
| タイトル | 血管平滑筋細胞の表現型変化に及ぼすエストロゲンと植物エストロゲンの影響の比較 : 動脈硬化抑制との関連からの検討 | |||||
| タイトル | ||||||
| タイトル | Comparison of the Effect of Estrogen and Phytoestrogen on Phenotypical Changes of Vascular Smooth Muscle Cells : A Study in Relation to the Suppression of Atherosclerosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.18878/00001716 | |||||
| ID登録タイプ | JaLC | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 著者名(日） |
福島, 久美
× 福島, 久美× 西田, 昌司 |
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| 著者名(英) |
FUKUSHIMA, Kumi
× FUKUSHIMA, Kumi× NISHIDA, Masashi |
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| 著者所属（日） | ||||||
| 値 | 神戸女学院大学人間科学部 | |||||
| 著者所属（日） | ||||||
| 値 | 神戸女学院大学人間科学部人間科学専攻 | |||||
| 要旨（英） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Randomized clinical trials on the effect of the hormone replacement therapy showed that oral administration of 17β-estradiol did not reduce the risk of cardiovascular disease. Furthermore, it increased the risk of breast cancer in a studied population. In contrast, isoflavone, one of the phytoestrogens abundant in soy beans, is supposed to protect vasculatures from atherosclerosis, because of a low incidence of coronary heart disease in Asian countries where high level of soy products is consumed. Therefore we compared the effects of 17β-estradiol and isoflavone on the development of atherosclerosis using cultured smooth muscle cells. Previous studies mainly examined the reduction of risk factors such as lipid metabolism and the prevention of early lesion such as fatty streak by estrogen-like substances. In this study, we divided atherosclerosis into three stages and focused on their effects on vascular smooth muscle cells. We examined how estrogen and phytoestrogen affects on three phenotypes of smooth muscle cells: migration, uptake of modified low density lipoprotein (LDL), and type V collagen synthesis. Estrogen suppressed smooth muscle cell migration induced by platelet-derived growth factor (PDGF)-BB from the physiological concentration, enhanced uptake of modified LDL and synthesis of type V collagen only at the higher concentration. Isoflavone also inhibited cell migration at the physiological concentration, but this effect could not be detected at the higher concentration. As for the uptake of modified LDL, isoflavone did not enhance until 10μM. Also it induced synthesis of type V collagen at lOpM, but did not show significant difference at the higher concentrations. These data suggest that both estrogen and isoflavone prevent atherogenic plaque formation by vascular smooth muscle cells, but may promote plaque instabilization by the alteration of extracellular matrix. This study emphasizes the need to evaluate influences of estrogen and isoflavone on each step of the atherosclerotic plaque formation. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00085725 | |||||
| 書誌情報 |
神戸女学院大学論集 en : KOBE COLLEGE STUDIES 巻 52, 号 1, p. 135-148, 発行日 2005-07-15 |
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