{"created":"2023-06-19T10:53:48.279466+00:00","id":1896,"links":{},"metadata":{"_buckets":{"deposit":"d20b8c3f-068f-4054-bb84-96ea1c98e721"},"_deposit":{"created_by":3,"id":"1896","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1896"},"status":"published"},"_oai":{"id":"oai:kobe-c.repo.nii.ac.jp:00001896","sets":["40:254:255"]},"author_link":["3484","3194"],"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"117","bibliographicPageStart":"105","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"神戸女学院大学論集"},{"bibliographic_title":"KOBE COLLEGE STUDIES","bibliographic_titleLang":"en"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平林, 玲子"},{"creatorName":"ヒラバヤシ, レイコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西田, 昌司"},{"creatorName":"ニシダ, マサシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3194","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040283783","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040283783"},{"nameIdentifier":"40283783","nameIdentifierScheme":"KAKEN-研究者検索","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000040283783/"}]}]},"item_2_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HIRABAYASHI, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIDA, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3194","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040283783","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040283783"},{"nameIdentifier":"40283783","nameIdentifierScheme":"KAKEN-研究者検索","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000040283783/"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"要旨（英）","attribute_value_mlt":[{"subitem_description":"Cigarette smoke contains more than 4,000 chemical substances and causes deleterious effects on various human organs. As the lung is the first organ that is exposed to these substances, cigarette smoking induces respiratory diseases such as inflammation, remodeling and cancer in high incidence. We examined whether nicotine, one of the major bioactive substances in cigarette smoke, disrupts lung immune function against respiratory diseases. We tested the effect of nicotine on antimicrobial activity of alveolar macrophages (AMs) by evaluating nitric oxide (NO) production and phagocytosis. NO production was assessed by measuring N0_2^-/N0_3^-concentration using Griess reagent method and phagocytosis was evaluated by the intake of fluoroprobe-labeled latex beads. Rat AM harvested by blonchoalveolar lavage (BAL) and mouse AM cell line (AMJ2-C11) were treated with 0-500μM of nicotine for 24h. Nicotine in high concentration (250, 500μM) enhanced phagocytosis of latex beads in both AMs significantly. In addition, the high concentration of nicotine (over 100μM) increased NO production by AMs. These results suggeste that nicotine enhances inflammatory function of AMs in high concentration. The over activation of inflammatory response by nicotine may contribute to the induction of respiratory injury by cigarette smoking.","subitem_description_type":"Other"}]},"item_2_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18878/00001857","subitem_identifier_reg_type":"JaLC"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00085725","subitem_source_identifier_type":"NCID"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"神戸女学院大学人間科学研究科博士前期課程"},{"subitem_text_value":"神戸女学院大学人間科学部環境・バイオサイエンス学科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2008-06-01"}],"displaytype":"detail","filename":"KJ00005180949.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","license_note":"神戸女学院大学研究所","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005180949","url":"https://kobe-c.repo.nii.ac.jp/record/1896/files/KJ00005180949.pdf"},"version_id":"6e79ff27-254a-4525-b97f-d7036a1961cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ニコチン","subitem_subject_scheme":"Other"},{"subitem_subject":"肺胞マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"貪食能","subitem_subject_scheme":"Other"},{"subitem_subject":"喫煙","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化窒素","subitem_subject_scheme":"Other"},{"subitem_subject":"nicotine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alveolar macrophages","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phagocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"smoking","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitrix oxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肺胞マクロファージの炎症反応に及ぼすニコチンの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺胞マクロファージの炎症反応に及ぼすニコチンの影響"},{"subitem_title":"The Effect of Nicotine on Inflammatory Response of Alveolar Macrophages","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["255"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-06-01"},"publish_date":"2008-06-01","publish_status":"0","recid":"1896","relation_version_is_last":true,"title":["肺胞マクロファージの炎症反応に及ぼすニコチンの影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T11:31:48.342654+00:00"}