{"created":"2023-06-19T10:55:24.507153+00:00","id":6074,"links":{},"metadata":{"_buckets":{"deposit":"8a64b012-9dee-4181-b50f-877cc572ee8d"},"_deposit":{"created_by":21,"id":"6074","owners":[21],"pid":{"revision_id":0,"type":"depid","value":"6074"},"status":"published"},"_oai":{"id":"oai:kobe-c.repo.nii.ac.jp:00006074","sets":["29"]},"author_link":["6100","6099"],"item_10006_date_granted_31":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-17"}]},"item_10006_degree_grantor_29":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神戸女学院大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"34510","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_28":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(人間科学）"}]},"item_10006_description_27":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"メタボリックシンドロームでは、過剰な内臓脂肪蓄積により、脂肪組織からのアディポサイトカイン分泌異常を認め、様々な代謝異常を引き起こす。さらに病態の進行により、糖尿病、動脈硬化症、NASHのような生活習慣病を発症する。本研究では、これらの予防もしくは早期治療を行うため、メタボリックシンドロームに関与するバイオマーカーとして、アディポサイトカインのTNFαとLeptin、NASHバイオマーカー候補fCK18の高感度測定系を確立した。","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_32":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第5号"}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18878/00005975","subitem_identifier_reg_type":"JaLC"}]},"item_10006_publisher_25":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"山田 みのり"}]},"item_10006_text_30":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2022"}]},"item_10006_version_type_34":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, みのり"},{"creatorName":"ヤマダ, ミノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"6099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMADA, Minori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6100","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-27"}],"displaytype":"detail","filename":"メタボリックシンドロームに関与するバイオマーカー測定系の確立.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"メタボリックシンドロームに関与するバイオマーカー測定系の確立","url":"https://kobe-c.repo.nii.ac.jp/record/6074/files/メタボリックシンドロームに関与するバイオマーカー測定系の確立.pdf"},"version_id":"87427c79-06d3-4a0a-838f-6d3a6d7100bd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メタボリックシンドローム","subitem_subject_scheme":"Other"},{"subitem_subject":"TNFα","subitem_subject_scheme":"Other"},{"subitem_subject":"レプチン","subitem_subject_scheme":"Other"},{"subitem_subject":"非アルコール性脂肪肝炎","subitem_subject_scheme":"Other"},{"subitem_subject":"フラグメント化サイトケラチン18","subitem_subject_scheme":"Other"},{"subitem_subject":"Metabolic syndrome, tumor necrosis factor-α：TNFα","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Leptin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nonalcoholic steatohepatitis : NASH","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fragmented cytokeratin 18：fCK18","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"メタボリックシンドロームに関与する  バイオマーカー測定系の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メタボリックシンドロームに関与する  バイオマーカー測定系の確立"}]},"item_type_id":"10006","owner":"21","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-04-27"},"publish_date":"2023-04-27","publish_status":"0","recid":"6074","relation_version_is_last":true,"title":["メタボリックシンドロームに関与する  バイオマーカー測定系の確立"],"weko_creator_id":"21","weko_shared_id":21},"updated":"2023-06-19T11:09:03.506192+00:00"}