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活性化マクロファージのNO産生に及ぼすエタノールと性差の影響 : 動脈硬化発症との関連から
https://doi.org/10.18878/00001764
https://doi.org/10.18878/000017646a9eefe9-af5b-4710-ac6d-b043084125c5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004441282 (1.0 MB)
|
神戸女学院大学研究所
|
| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-20 | |||||
| タイトル | ||||||
| タイトル | 活性化マクロファージのNO産生に及ぼすエタノールと性差の影響 : 動脈硬化発症との関連から | |||||
| タイトル | ||||||
| タイトル | Effects of Ethanol on the NO Production of Macrophages from Male and Female Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.18878/00001764 | |||||
| ID登録タイプ | JaLC | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 著者名(日） |
杉本, 香奈
× 杉本, 香奈× 西田, 昌司 |
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| 著者名(英) |
SUGIMOTO, Kana
× SUGIMOTO, Kana× NISHIDA, Masashi |
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| 著者所属（日） | ||||||
| 値 | 神戸女学院大学人間科学研究科人間科学科専攻博士前期課程 | |||||
| 著者所属（日） | ||||||
| 値 | 神戸女学院大学人間科学部 | |||||
| 要旨（英） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Alcohol drinking is supposed to be one of risk factors of atherosclerosis. The risk of alcohol intake was mainly evaluated in male subjects, because of high percentage of drinking population in male. However, atherosclerosis is a typical disease that has sexual difference in morbidity and mortality. Therefore, we investigated whether ethanol causes different effects on macrophages, which play a pivotal role in the initiation and the development of atherosclerosis, from different sex origin. Peritoneal macrophages were isolated from rats stimulated with lipopolysaccharide. NO production was measured as an index of macrophage activation by Griess reagent method (NO_3^-/NO_2^- concentration) and NO sensitive fluorescent dye (relative NO concentration). Ethanol reduced NO_3^-/NO_2^-concentration from500mM and NO production from 300mM in macrophages from male rats. Ethanol reduced both parameters in macrophages from female rats in less extent. The addition of 17β-estradiol to macrophages suppressed the reduction of NO production from macrophages by ethanol. However, there was no statistical difference in both experiments. These results suggest that ethanol reduces the activation of macrophages and may suppress the progression of atherosclerosis. Although the protective effect of ethanol was limited in female rats compared with male rats, there was no significant sexual difference in our model. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00085725 | |||||
| 書誌情報 |
神戸女学院大学論集 en : KOBE COLLEGE STUDIES 巻 53, 号 1, p. 115-130, 発行日 2006-07-20 |
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